Immunogenicity and efficacy of Russian live attenuated and US inactivated influenza vaccines used alone and in combination in nursing home residents
Identifieur interne : 000152 ( 1957/Analysis ); précédent : 000151; suivant : 000153Immunogenicity and efficacy of Russian live attenuated and US inactivated influenza vaccines used alone and in combination in nursing home residents
Auteurs : Larisa G. Rudenko [Russie] ; Nancy H. Arden [États-Unis] ; Elena Grigorieva [Russie] ; Anatoli Naychin [Russie] ; Andrei Rekstin [Russie] ; Alexander I. Klimov [États-Unis] ; Svetlana Donina [Russie] ; Julia Desheva [Russie] ; Robert C. Holman [États-Unis] ; Angel Deguzman [Russie] ; Nancy J. Cox [États-Unis] ; Jacqueline M. Katz [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2001.
English descriptors
- Teeft :
- Antibody response, Antibody responses, Antibody titers, Attenuated, Attenuated vaccine, Chronic diseases, Clin microbiol, Combination vaccine groups, Combination vaccine strategies, Disease control, Dos, Elderly people, Elderly persons, Gmt, Immunogenicity, Intranasal, Nasal, Nursing home, Nursing home residents, Nursing homes, Other vaccine groups, Placebo, Placebo group, Post rise, Posta riseb, Postvaccination, Postvaccination gmts, Postvaccination serum, Postvaccination titers, Prevaccination, Prevaccination titers, Reassortant, Responder, Rudenko, Serum antibody response, Study participants, Titer, Treatment groups, Trivalent, Trivalent vaccine, Trivalent vaccines, Vaccination, Vaccine, Vaccine antigens, Vaccine group, Vaccine groups, Vaccine immunogenicity, Virus vaccine, Virus vaccines.
Abstract
Abstract: The immunogenicity and efficacy of Russian live attenuated and US inactivated trivalent influenza vaccines administered alone or in three different combinations were evaluated in a randomized, placebo-controlled, double-blinded study of 614 elderly or chronically ill nursing home residents in St. Petersburg, Russia during the 1996–97 influenza season. Postvaccination serum antibody responses were more frequent among individuals administered the combination vaccines than among those vaccinated with live or inactivated vaccine alone. Only individuals who received live vaccine, alone or in combination with inactivated vaccine, achieved significant postvaccination increases in virus-specific nasal IgA. Efficacy in preventing laboratory-confirmed influenza in vaccinated versus nonvaccinated individuals was 67% (95%CI, 36–81%) for recipients of a combination of the vaccines compared with 51% (95%CI, −17–79%) for recipients of live vaccine alone and 50% (95%CI, −26–80%) for recipients of inactivated vaccine alone. These results suggest that administration of a combination of influenza vaccines may provide a strategy for improved influenza vaccination of elderly people.
Url:
DOI: 10.1016/S0264-410X(00)00153-5
Affiliations:
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Postvaccination serum antibody responses were more frequent among individuals administered the combination vaccines than among those vaccinated with live or inactivated vaccine alone. Only individuals who received live vaccine, alone or in combination with inactivated vaccine, achieved significant postvaccination increases in virus-specific nasal IgA. Efficacy in preventing laboratory-confirmed influenza in vaccinated versus nonvaccinated individuals was 67% (95%CI, 36–81%) for recipients of a combination of the vaccines compared with 51% (95%CI, −17–79%) for recipients of live vaccine alone and 50% (95%CI, −26–80%) for recipients of inactivated vaccine alone. These results suggest that administration of a combination of influenza vaccines may provide a strategy for improved influenza vaccination of elderly people.</div></front></TEI><affiliations><list><country><li>Russie</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Russie"><noRegion><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G" last="Rudenko">Larisa G. Rudenko</name></noRegion><name sortKey="Deguzman, Angel" sort="Deguzman, Angel" uniqKey="Deguzman A" first="Angel" last="Deguzman">Angel Deguzman</name><name sortKey="Desheva, Julia" sort="Desheva, Julia" uniqKey="Desheva J" first="Julia" last="Desheva">Julia Desheva</name><name sortKey="Donina, Svetlana" sort="Donina, Svetlana" uniqKey="Donina S" first="Svetlana" last="Donina">Svetlana Donina</name><name sortKey="Grigorieva, Elena" sort="Grigorieva, Elena" uniqKey="Grigorieva E" first="Elena" last="Grigorieva">Elena Grigorieva</name><name sortKey="Naychin, Anatoli" sort="Naychin, Anatoli" uniqKey="Naychin A" first="Anatoli" last="Naychin">Anatoli Naychin</name><name sortKey="Rekstin, Andrei" sort="Rekstin, Andrei" uniqKey="Rekstin A" first="Andrei" last="Rekstin">Andrei Rekstin</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Arden, Nancy H" sort="Arden, Nancy H" uniqKey="Arden N" first="Nancy H" last="Arden">Nancy H. Arden</name></region><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J" last="Cox">Nancy J. Cox</name><name sortKey="Holman, Robert C" sort="Holman, Robert C" uniqKey="Holman R" first="Robert C" last="Holman">Robert C. Holman</name><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M" last="Katz">Jacqueline M. Katz</name><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I" last="Klimov">Alexander I. Klimov</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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